|
PRONALEN
SENSITIVE SKIN |
|
A plant complex intended
to alleviate the processes that cause skin irritation caused either
by soaps, solvents, physical agents or the sun radiation. |
| From: Tulsi (Ocimum Sanctum
Leaf) and Lady 's Thistle (Silybum Marianum Fruit) |
| Ingredient: 0.04% Ursolic
Acid and 0.4% Silymarin. |
| COSMETIC PROPERTIES |
| Inflammation is a complex process
of sequential changes in the tissues in reply to lesions (aggressions).
The term irritation is the common denomination of an inflammatory
process, although it is always associated with processes that occur
on the skin. An irritative process may be unleashed by external
environmental causes such as UV radiation, chemical and biological
agents and internal causes (of immunological origin, enzymes and
prostaglandins). |
| Prostaglandins are a family
of unsaturated fatty acid derivatives that are obtained from arachidonic
acid (figure 4). This pathway is activated by physical, chemical
and hormonal stimuli and causes the hydrolysis of the phospholipids
by the action of phospholipase A2, to release arachidonic acid.
From this point, and by the later action of the enzymes, cyclooxygenase
and lipooxygenase, the cyclic endoperoxides are formed and then
the prostaglandins (PG), prostacyclins and thromboxanes. |
| When a lesion occurs, the damaged
tissue releases a large amount of inflammatory mediators, mainly
histamine, bradykinin, serotonin, PG, etc., which cause an increase
in the local blood flow (erythema) and a permeability of the venous
capillaries towards the tissues, resulting in the formation of a
local extracellular oedema. Then the injured area is surrounded
by a wall formed by the coagulation of the exuded products of the
tissues. Soon after the inflammation has begun, this area is invaded
by macrophages (histiocytes) and neutrophiles, which release proteolitic
enzymes, mainly elastase, and carry out cleaning functions to remove
the toxic, infectious agents. The process ends with the recovery
of the damaged area with cicatrisation of the tissues. |
|
|
Figure 1. Mechanism
of action of the irrititative process
EFFICACY TEST
|
| Comparison with -Bisabolol
and Chamomile Extract |
| The anti-irritant effect of
the Pronalen Sensitive Skin was then compared with *-Bisabolol and
Chamomile Extract H.G.(Cod.4370). All of these products were tested
at a concentration of 3.5% in active substance. |
|
|
| The results obtained (graph
4) show that the products *-Bisabolol, Chamomile Extract H.G (Cod.4370)
and Pronalen Sensitive Skin cause a statistically significant delay
in the appearance of haemorrhagic lesions irritant-induced. The
Increase in Relative Time ( t%) was 21.1% for the Chamomile Extract,
29.6% for the *-Bisabolol and 48,1% for the Pronalen Sensitive Skin. |
| These results allow us to state
that Pronalen Pieles Sensibles presents a marked anti-irritant activity,
1.6 and 2.3 times higher than the *-Bisabolol and Chamomile Extract,
respectively |
| RECOMMENDED DOSAGE : 2-5
% |
